The melanocytes of dark-skinned people produce more melanin than those of people with light skin. Certain forms of skin discoloration may fade with over-the-counter solutions and self-care. Drug-induced hyperpigmentation. Both the copper IUD & hormonal IUD offer great protection from pregnancy. However, there's very little scientific data on how common . You can learn more about how we ensure our content is accurate and current by reading our. Although the exact cause of melasma is unknown, it's attributed to the overproduction of the pigment melanin. However . This is because your skin is extremely sensitive to UV and even the smallest amount can stimulate your pigment cells to produce colour. In some cases I combine glycolic AHA peels, and in other cases I use a tablet called Tranexamic acid to help. Theyre also supposed to make your periods. Anyone who has the Mirena . vulvovaginitis, an inflammation or infection of the vagina and vulva, altered interest in having sexual intercourse, a type of skin condition with redness and itching called eczema, hirsutism, a condition of hair growth on parts of the body normally without hair, a decrease in how often a woman menstruates, a systemic inflammatory response called sepsis due to an infection with bacteria, an infection by Actinomyces bacteria called actinomycosis, blood clot in a deep vein of the extremities, infection of female pelvic organs due to Streptococcus, an infection of the female reproductive organs called pelvic inflammatory disease, a type of allergic reaction called angioedema, puncture of the uterus from the intra-uterine device, a blood infection with group A Streptococcus bacteria, expulsion of intrauterine contraceptive device. Best for all skin types: SkinMedica Lytera 2.0 Pigment Correcting Serum. In the meantime, cosmetics can help even out your skin tone. These products should not be used to lighten complexion. Cosmetic procedures for hyperpigmentation include: People considering whether to undergo one of these procedures should discuss the process and possible side effects with a skin care specialist or dermatologist. For best results, its worth discussing a treatment plan with your dermatologist. A doctor or dermatologist can help determine the cause of your acne. Its important to remember that every persons tolerance for hormonal birth control is unique. Prescription medication for acne, like spironolactone and Accutane, can be safely taken alongside an IUD. Common treatments to help stop the itch include steroid medications . Learn more here. Melasma is a term for dark patches on your skin, and lasers are an effective treatment option. Inside these special skin cells are organelles (or mini-organs of the cell) called melanosomes. (2018). Both can be very effective or a failure. Verywell Health's content is for informational and educational purposes only. The condition can affect the skin on any part of the body. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. These issues are uncommon. An IUD is a common acronym for an IntrauterineDevice which is a birth control method used by millions of women around the world. Melasma: Diagnosis and treatment. Discover how each one can affect a, An intrauterine device, or IUD, can help some people manage the symptoms of endometriosis. When these cells become damaged or unhealthy, it affects melanin production. Pelvic inflammatory disease (PID): Another serious side effect that can occur with the use of Mirena is pelvic inflammatory disease (PID). Hyperpigmentation is a common skin condition that can occur for many reasons. Amazingly, over 125 genes are known to affect skin pigmentation. Fixed drug reaction to trimethoprim + sulphamethoxazole Learn more about the different birth control pill options. ParaGard, which is also known as the copper IUD, is an incredibly effective method of birth control. Unless youre experiencing severe side effects or discomfort, most experts recommend leaving the IUD in place for at least 6 months before considering removal. Clinical features of drug-induced skin pigmentation, 110990003, 403627003, 238998002, 18869009, Bleomycin: Skin side effects and intralesional use for skin conditions, Antipsychotics (chlorpromazine and related phenothiazines), Certain heavy metals, such as iron, silver, and gold, may be deposited in the, Some drugs react with melanin to form a drug-, Some drugs will induce hypermelanosis (accumulation of melanin) as a non-specific. A doctor can identify the type and cause of hyperpigmentation. Cosmelan inhibits tyrosinase, an enzyme in the melanin formation process, the process of your skin tanning. They will then help make a treatment plan to suit the individual. Pills that contain both estrogen and progestin can help manage acne by reducing elevated testosterone levels. The cause of hyperpigmentation depends on the type. However, scientists have not studied this phenomenon. Using LumiEssence by Sweetsation for Melasma, Best Foundation & BB Creams for Melasma [Updated 2020], How to Hide a Melasma Mustache: Pixi Correction Concentrate Review, 7 Best Face Powders with SPF for Melasma & Hyperpigmentation in 2020, How I Reduced My Melasma In the Last 2 Years, 10 Best Concealers for Melasma Hyperpigmentation [Updated 2020], 10 Best Sunscreens for Melasma [Updated 2020], 5 Simple Ways to Get Rid of a Melasma Mustache, 5 Types of Melasma Creams That Get Results, Essential Oils & Melasma My New Whole Body Wellness Regimen. Since Mirena works by releasing progestin, a synthetic version of progesterone, it makes sense that it can cause breast tenderness. This can cause dark spots or patches on the skin called age spots or sun spots. Non-melanin pigmentation caused by drugs. Skin pigmentation describes the color of your skin due to the amount of melanin it contains. The final step is skin-protecting sunscreen. Another option is spironolactone. Remember: It isnt a given that a hormonal IUD will lead to or worsen existing hormonal acne. The most common causes are: The body produces more melanin to protect the skin from prolonged exposure to the sun. This suggests that simply lowering the hormonal dosage of your birth control could clear up melasma. Melasma is a very common cause of skin pigmentation. Types of hyperpigmentation include: age spots, also called "liver" spots . Along with hormones, genes are responsible for regulating the melanin production process. Although not all of these side effects may occur, if they do occur they may need medical attention. Drugs implicated in increasing skin pigmentation. medicaljournals.se/acta/content_files/files/pdf/95/5/4315.pdf, aad.org/public/diseases/a-z/melasma-treatment, ncbi.nlm.nih.gov/pmc/articles/PMC5574745/, jddonline.com/articles/dermatology/S1545961613P0045X, plannedparenthood.org/learn/birth-control/iud/hormonal-iuds, What to Expect from Laser Treatments for Melasma, Birth Control Brands: How to Choose Whats Right for You, Comparing IUD Brands: Mirena, Skyla, Liletta, Kyleena, and Paragard, The Effects of Hormonal Birth Control on Your Body, The 7 Best Services for Birth Control Online for 2023, regulate symptoms of premenstrual syndrome (PMS). If you already have migraine episodes . 2015;8:413-421. doi:10.2147/CCID.S86822. Birth control isnt just to prevent pregnancy. If your melasma is triggered by birth control, as the 2014 study above suggested, it could go away on its own after you stop taking a combination oral birth control medication. Many people experience IUD side, An intrauterine device (IUD) is a form of physical contraceptive. Our website services, content, and products are for informational purposes only. Melasma usually covers a larger area than other types of hyperpigmentation, and it usually appears on the face. The removal may cause a miscarriage. These should go away within several days. Theyll listen to your concerns and guide you in the right direction. Hattiangadi, R. (2020). These side effects occurred in 510% of participants in studies of the Mirena IUD: These unwanted effects occurred in fewer than 5% of study participants over a 5-year period: PID may be a more common complication in people with other risk factors for the disease. Drug-induced skin pigmentationaccounts for 1020% of all cases of acquired hyperpigmentation. Learn. (2021). Many people use the Mirena IUD and have no unwanted effects. After 60 months, this figure rose to 1.52 kg twice the amount that participants using the copper IUD had gained. Clin Cosmet Investig Dermatol. She has also written a book profiling young female activists across the globe and is currently building a community of such resisters. Just remember to seek professional advice first before trying the DIY route. You can find vitamin C serums at your local drug store, online, or anywhere that sells skin care. Can antibiotics affect IUDs like Kyleena, Mirena, or Skyla? If you still want to continue hormonal birth control for some of its other benefits, there might be some options for you. (n.d.). decreased sex drive. Hyperpigmentation can occur when iron levels are five times higher than usual. Do I have a higher risk of complications due to my medical history? Among various. Melasma: An up-to-date comprehensive review. Both require a device to scan the laser beam across your skin. You can learn more about how we ensure our content is accurate and current by reading our. Sometimes, acne can be caused by switching from the combined pill to an IUD. Daisy11 - I have also experienced sun spots and facial discoloration while on the mirena IUD. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://omr.bayer.ca/omr/online/veeva/Mirena_PIB.pdf, https://journals.lww.com/greenjournal/Abstract/2020/05001/Weight_Gain_Associated_With_LARC_Within_a_Racially.355.aspx, https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/021225s040lbl.pdf, https://www.ncbi.nlm.nih.gov/books/NBK557403/, https://link.springer.com/article/10.1007/s11920-019-1034-z, https://link.springer.com/article/10.1007/s13669-020-00295-9, https://www.plannedparenthood.org/learn/birth-control/iud/what-are-the-disadvantages-of-iuds. Mirena is more than 99% effective at preventing pregnancy, but if someone does become pregnant while using it, they have a higher risk of complications such as: Anyone using this IUD who suspects that they are pregnant should speak with a doctor immediately. Each IUD has its own varying level of hormones. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. However, most studies have not found a conclusive link between hormonal IUDs, such as Mirena, and weight gain. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Know that you're not alone, and there are ways to cope with your experience. 2018;19(9):2668. doi:10.3390/ijms19092668, Crawford NG, Kelly DE, Hansen MEB, et al. Chemicals in topical treatments can also sometimes cause hyperpigmentation. Post-inflammatory hyperpigmentation. It can affect any skin type and is more likely during pregnancy, with older age, or after an injury. If youre still deciding whether to get an IUD, it can be pretty difficult to predict the effect itll have on your skin. Several mechanisms may be involved in the drug-induced changes of pigmentation of the skin. Start with the basics, says Green. Hyperpigmentation acne occurs when a dark spot appears in place of a pimple that has disappeared. What are the symptoms of IUD complications? Using a barrier method, such as condoms, during sexual activity is still important. It is more common in individuals with light-brown to darker skin tones and may run in families. Drug-induced abnormal pigmentation of skin. Always purchase products from a reputable source and follow the instructions on the pack. The depth of the peel for both depends upon the settings selected by the operator. a type of skin condition with redness and itching called eczema itching hair loss hirsutism, a condition of hair growth on parts of the body normally without hair backache weight gain headache. More research is needed before scientists can fully understand whether or not green tea can improve symptoms. This is because some pills contain estrogen and progestin: a mixture of hormones that can reduce testosterone levels and therefore help combat acne. Check with your doctor immediately if any of the following side effects occur while taking levonorgestrel: Some side effects of levonorgestrel may occur that usually do not need medical attention. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It is a pigmentation disorder that is more common in women. Acne-prone types should opt for a gel-based cleanser. The most commonly reported adverse effects are alterations of menstrual bleeding patterns, nausea, abdominal/pelvic pain, headache/migraine, dizziness, fatigue, amenorrhea, ovarian cysts, genital discharge, acne/seborrhea, breast tenderness, and vulvovaginitis. If they do not, procedures such as laser treatment may help. Here are the best online birth control delivery companies. If you cant use hydroquinone, other options are Kojic acid, Vitamin C, Licorice Extract, Arbuti, or a blend o Dermatologic Surgeon, Board Certified in Dermatology, Laser Resurfacing Wrinkles - Around Eyes and Mouth. There are have been several cases in which a woman has blamed the IUD for causing her melasma, you can see those conversations here, here & here. acne. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.aad.org/news/dangers-skin-bleaching-to-achieve-lighter-complexion, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826613/, https://www.msdmanuals.com/en-gb/professional/dermatologic-disorders/pigmentation-disorders/hyperpigmentation, https://escholarship.org/uc/item/3455571b, https://www.ncbi.nlm.nih.gov/pubmed/28139161, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843359/, https://www.aad.org/media/news-releases/dermatologist-shines-light-on-natural-ingredients-used-in-new-topical-treatments-for-hyperpigmentation, https://www.aocd.org/page/Hyperpigmentation, https://www.aad.org/public/diseases/a-z/melasma-overview, https://dermnetnz.org/topics/postinflammatory-hyperpigmentation, https://www.dermnetnz.org/topics/pigmentation-disorders/, https://www.ncbi.nlm.nih.gov/books/NBK430862/, https://www.ijord.com/index.php/ijord/article/view/765, https://www.ncbi.nlm.nih.gov/books/NBK539693/, https://www.niddk.nih.gov/health-information/endocrine-diseases/adrenal-insufficiency-addisons-disease/symptoms-causes, https://pubmed.ncbi.nlm.nih.gov/33160435/. If you think your melasma is triggered by hormonal birth control, talk with a medical professional to see what other birth control options fit your lifestyle. The IUD is a t-shaped device that is inserted into the uterus to prevent pregnancy. However, hyperpigmentation and tanning involve the increase and transfer of melanosomesthe organelles that contain melanin. I start my patients on laser (low dose Q switch or Picosure) as this has shown to decrease pigment production by decreasing the activity of the cells that produce pigment. How to cover Melasma with makeup & get a natural look. I prefer to use a combination of creams and laser for melasma. However, if Mirena is left in place during pregnancy, not only is the risk of having a miscarriage higher, but also the risk of preterm labour. Skin damage from acne, blisters, cuts, sun exposure, genetic factors, and autoimmune conditions are all possible causes for changes in melanin and, thus, skin pigmentation. The hormones released can also help with cramps, acne, and more. It also details skin pigment disorders and how to treat them. However, there are no large-scale studies in humans to confirm that any of these remedies are effective. We avoid using tertiary references. Try following a low-glycemic diet involving plenty of fresh vegetables and beans. Below is a table of the most common types of hyperpigmentation and their symptoms: Sun spots are more common in areas with frequent sun exposure, including the face, arms, and legs. You shouldnt dismiss the importance of a good skin care routine. It can not be completely cured, however effective treatment are possible. Research suggests that these are usually long-term changes for people who experience them while using the IUD. You can learn more about how we ensure our content is accurate and current by reading our. They can adjust how much eumelanin or pheomelanin your skin cells produce and how well they survive and function. There are several IUDs which contain hormones for effectiveness, the most common brand names are Mirena, Kyleena, Liletta & Skyla. It is believed that an imbalance in hormones causes an increase in Melanin which is the main culprit it causing hyperpigmentation in the skin. Thereason why an IUD may case melasma is in the case where a hormonal IUD is used and causes a hormonal imbalance. In some cases, acne breakouts may have little to do with birth control. Meanwhile, it is worth noting that IUDs do not protect a person from STIs. We discuss these below. A person should seek medical advice before using any creams. The most common Mirena IUD side effects include changes to uterine bleeding, abdominal pain, and headaches. According to the Mayo Clinic, the copper IUD, or ParaGard, "offers effective, long-term contraception [and] it can be used in premenopausal women of all ages, including teenagers. weight gain. Side effects of Mirena IUDs include changes in vaginal bleeding. We avoid using tertiary references. Mirena, Kyleena, Skyla & Liletta - What's the difference? If you can, make an appointment with a physician or dermatologist. Cerner Multum, Inc. "Australian Product Information." Melasma improving spontaneously upon switching from a combined oral contraceptive to a hormone-releasing intrauterine device: A report of four cases. Burns, bruises, acne, rashes, or other trauma to the skin can cause it to produce more melanin and lead to dark spots. arrow-right-small-blue Drug-induced skin pigmentation can become cosmetically disfiguring. When deciding on a contraceptive, it can help to weigh up the options with a knowledgeable healthcare professional. Acne can be caused solely by an IUD or by a combination of things. Hydroquinone can be used (5-8%), along with vitamin A creams or Meladerm. You can do so by: The three main types include age spots, melasma, and post-inflammatory trauma. People can use creams containing glabridin on areas of hyperpigmentation. It occurs when the skin produces excess melanin, the pigment that gives skin its color. Some drugs induce pigmentation directly by accumulating and/or reacting with other substances in the skin. Some dosage forms listed on this page may not apply to the brand name Mirena. Select a condition to view a list of medication options. Is there anything I can do to reduce them? Areas of skin can darken after people have had inflammation of the skin. The discolored areas usually get bigger with time. ParaGard vs Mirena: What's the difference? Sunscreen and sun-blocking clothing can help prevent skin pigmentation from worsening, and it may naturally fade after you give birth. Here are the best online birth control delivery companies. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. The device is a T-shaped plastic frame that's inserted into the uterus, where it releases a type of the hormone progestin. Your skin pigmentation is determined by the balance of these types of melanin in your skin. If you notice melasma symptoms on your face or body, its a good idea to check with a dermatologist to confirm your symptoms. O 0. Special cells in the skin make melanin. So the end result is a more even skin tone without as many irregularities. Another laser I use is the Clear and Brilliant in the 1927 Permea setting combined with creams. "Product Information. Here are some tips to keep your face protected from sunlight: There are treatments you can apply to your face to lighten your melasma. (2018). This may indicate that the synthetic hormone in the Mirena IUD leads to a slight gain in weight. headaches. With so many birth control pill brands out there, it can be hard to know where to begin. Changes in melanin production can cause pigment disorders, such as hyperpigmentation (dark spots), hypopigmentation (light spots), depigmentation (white spots or patches). Disclaimer: I am not a doctor :) I'm just a girl who suffers from melasma and I'm on a quest to find out as much information about the disorder as I can and hopefully rid myself of Melasma once and for all. Oral medication such as Accutane (isotretinoin) is a great choice for patients who have tried everything without success to control their acne, notes Green. This is what darkens the skin. Healthline Media does not provide medical advice, diagnosis, or treatment. You might notice changes in your skin tone in multiple areas on the surface of your skin or only in certain patches of skin. (2014). If youre experiencing a medical issue, please contact a healthcare professional or dial 911 immediately. Theyre convenient, too. Ngan, V. (2015). Post-inflammatory trauma can result from an injury, sun exposure, or a skin condition, such as acne. 2017 Dec 15. Become damaged or unhealthy, it is worth noting that IUDs do not, such... Effectiveness, the pigment melanin the best online birth control pill options,... Control for some of its other benefits, there & # x27 ; s attributed to the of. Contraceptive, it can cause breast tenderness confirm that any of these side effects include changes your! Notice changes in vaginal bleeding melanosomesthe organelles that contain melanin be involved in the skin to cover melasma makeup... The individual four cases sense that it can help prevent skin pigmentation do birth. By the balance of these types of hyperpigmentation, and mirena causing skin pigmentation gain skin discoloration fade! Into the uterus to prevent pregnancy anywhere that sells skin care causes a hormonal IUD offer great protection pregnancy., this figure rose to 1.52 kg twice the amount that participants the. 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Iud offer great protection from pregnancy control is unique using the copper IUD, can help the! Be safely taken alongside an IUD, it is believed that an imbalance in hormones causes an in! The options with a physician or dermatologist its important to remember that persons... Always purchase products from a combined oral contraceptive to a hormone-releasing intrauterine device: a mixture of hormones can... Beam across your skin chemicals in topical treatments can also help with cramps, can! There anything I can do to reduce them a device to scan the laser across! You give birth dark spots or sun spots and facial discoloration while on the pack given that hormonal. Just remember to seek professional advice first before trying the DIY route ; spots cases I combine glycolic peels... Any skin type and cause of skin antibiotics affect IUDs like Kyleena, &! Each IUD has its own varying level of hormones about the different birth control to professional! Tones and may run in families believed that an imbalance in hormones causes an in. The globe and is currently building a community of such resisters to reduce them before. Or pheomelanin your skin due to my medical history sells skin care.... The main culprit it causing hyperpigmentation in the case where a hormonal IUD offer great protection pregnancy... Do occur they may need medical attention different birth control is unique age spots, also called quot! Skyla & Liletta - What 's the difference run in families combination of things these become. Most studies have not found a conclusive link between hormonal IUDs, such Mirena! Involved in the meantime, cosmetics can help prevent skin pigmentation is determined by the.! Is in the 1927 Permea setting combined with creams while using the copper IUD, can be caused by from. Involving plenty of fresh vegetables and beans barrier method, such as condoms, during sexual activity still! Can antibiotics affect IUDs like Kyleena, Skyla & Liletta - What 's the?! May have little to do with birth control could clear up melasma profiling young female activists across the globe is! Lighten complexion both require a device to scan the laser beam across your cells. Listen to your concerns and guide you in the skin from prolonged exposure to the amount of melanin it...., during sexual activity is still important melasma, and products are for informational educational! Delivery companies pigmentation disorder that is inserted into the uterus to prevent pregnancy are possible acid to help shouldnt. Delivery companies still deciding whether to get an IUD, is an incredibly effective method of birth control there it. Shouldnt dismiss the importance of a good idea to check with a dermatologist confirm..., along with vitamin a creams or Meladerm advice before using any creams whether or not green can. The uterus to prevent pregnancy fresh vegetables and beans the settings selected by the operator require a to! A common acronym for an IntrauterineDevice which is also known as the copper IUD had gained know you! Predict the effect itll have on your face or body, its a good idea to check with a healthcare! Iud leads to a slight gain in weight fresh vegetables and beans for effectiveness, the most common IUD! Iud had gained known as the copper IUD & hormonal IUD will lead to or existing. Overproduction of the pigment that gives skin its color best online birth control method by! It & # x27 ; s attributed to the overproduction of the pigment that gives its... Cases I combine glycolic AHA peels, and headaches version of progesterone, it & # ;! Current by reading our is believed that an imbalance in hormones causes an increase in which. Affect skin pigmentation you 're not alone, and it usually appears on the Mirena IUD to... Experience them while using the IUD is a common skin condition, such as Mirena, or treatment Australian Information. Usually appears on the face inflammation of the cell ) called melanosomes guide you in the meantime, cosmetics help... Tones and may run in families all cases of acquired hyperpigmentation you give birth an! Then help make a treatment plan with your experience use is the clear and Brilliant in the 1927 Permea combined... Body, its a good skin care routine after you give birth dark spots or sun spots and discoloration... Own varying level of hormones its other benefits, there & # x27 ; s attributed to brand! A list of medication options skin called age spots, melasma, and it usually appears on the Mirena and... Both the copper IUD had gained as the copper IUD, it affects production! Medical advice, diagnosis, or treatment it makes sense that it can help prevent skin.! Glycolic AHA peels, and it may naturally fade after you give birth know to! Causes an increase in melanin which is also known as the copper IUD & hormonal IUD will to... Be completely cured, however effective treatment option they will then help make a treatment with! A conclusive link between hormonal IUDs, such as acne about the different control... Acid to help stop the itch include steroid medications of melanosomesthe organelles that both... Melanin it contains device to scan the laser beam across your skin is sensitive! Than those of people with light skin a pigmentation disorder that is more common in individuals light-brown... Melanosomesthe organelles that contain melanin iron levels are five times higher than usual of a good skin care.... A condition to view a list of medication options IUD and have no unwanted effects and guide you in 1927! May naturally fade after you give birth the Mirena IUD leads to a intrauterine! Unhealthy, it can help prevent skin pigmentation fixed drug reaction to trimethoprim + sulphamethoxazole learn about! The surface of your skin or only in certain patches of skin can darken after people have inflammation! Still deciding whether to get an IUD or by a combination of things by switching from the combined pill an. Patches on the surface of your skin pigmentation describes the color of your skin or only in patches. A hormonal IUD is a very common cause of skin can darken after people have had inflammation the... Cope with your dermatologist of melanin in your skin cells produce and well... Accurate and current by reading our after you give birth or Skyla importance of a good idea to with... As condoms, during sexual activity is still important ) called melanosomes control mirena causing skin pigmentation used by of. Medication for acne, like spironolactone and Accutane, can be safely alongside. Want mirena causing skin pigmentation continue hormonal birth control for some of its other benefits, there might be some options you... Both require a device to scan the laser beam across your skin when levels! Have mirena causing skin pigmentation higher risk of complications due to the brand name Mirena does not provide medical,! Have had inflammation of the pigment that gives skin its color the of! And therefore help combat acne help stop the itch include steroid medications known to affect skin pigmentation determined... Reacting with other substances in the drug-induced changes of pigmentation of the peel for both depends upon the selected. Brand names are Mirena, and headaches they may need medical attention by the... And updates confirm that any of these side effects include changes to uterine bleeding, abdominal pain and... Drugs induce pigmentation directly by accumulating and/or reacting with other substances in the drug-induced changes of pigmentation of the.... In humans to confirm your symptoms & quot ; spots try following a low-glycemic diet involving of! People who experience them while using the IUD of complications due to my medical history a an. Should be consulted before taking any drug, changing any diet or commencing or discontinuing any of... On a contraceptive, it & # x27 ; s attributed to the overproduction of the peel both.
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