Each tablet is formulated to provide minimum dosages of 1.2 mg/kg sarolaner, 24 g/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! Ive talked to Collie and Aussie owners who absolutely swear by their Seresto collars and others who are livid because they made their dogs neck bald! March 1, 2022 Learn what medications may be dangerous for your dog with the MDRI genetic mutation. In the United States, DEC (diethylcarbamazine) was sold as Filaribits or Nemacide, but they no longer appear to be on the market. Sixteen Collies homozygous for the MDR1 deletion mutation were included in the study. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. What Can Cause Seizures in Dogs? ? If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. So, I now need a good flea/tick med and would rather not get another pill for her to take. Plus, Simparica's protection lasts for five weeks (35 days), and it does not decrease at the end of the month. Though not meant for long-term treatment, it is excellent for short-term intervention in the case of severe infestations or for a dog who happened to pick up a few fleas on an outdoor ramble and is in need of some quick relief. I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. Mary. Sugar is almost 4 months old now! There are separate, specific subsections for the not-recommended Heartgard and Nexgard and the recommended Interceptor and Credelio. (Many products dont repel insects, and if they do are often very strong chemical formulations.). SIMPARICA was administered in a well-controlled US field study, which included a total of 479 dogs (315 dogs treated with SIMPARICA and 164 dogs treated with active control once monthly for three treatments). However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. The most common side effect of Simparica is vomiting, which can happen within the first hour or two after administration. I know it contains Ivermectin, so I am not sure this information is correct. Wash hands after handling the product. It was both well written, and concise. This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. Your sense of humor is enlightening also. Ive changed the label on the Seresto section and added some info to keep it current. ( I had to get a different vet for my pup because my current vet couldnt get him in to start his vacines for 2.5 months. The vet thought he would be nice and put Advantage Multi on our cats. She was obviously in discomfort. Once WSU has determined your dogs MDR1 status,board- certified veterinary pharmacologistDr. Katrina Mealey, who discovered the MDR1 genetic mutation in dogs and cats, can work with you and your veterinarian through our online portal to determine the best course of action should your pet need to be treated with a medication known to cause adverse reactions. The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. It made my Collies itch nonstop though, so I had to wash it off a day after application. Capstar can be used with heartworm products and some other flea products (see link above for compatibility chart), and it can be given to pregnant or nursing dogs and cats, and even puppies or kittens that are older than 4 weeks or heavier than 2 pounds. Wondercide sounds like an excellent place to start as far as flea and tick prevention, and I hope it will be effective against mosquitoes, too. Since Collies and cats go together so well, I have to include this caution for cats: Some ingredients used to kill ticks, such as permethrin (used in K9 Advantix and other products) and amitraz (used in Certifect and the Preventic collar), are toxic to cats, which can be a problem in a household that includes both, especially if they are friendly with each other. If you have cats that share sleeping space with and/or like to groom your dogs, Advantix is probably not the best product for you. Dash is MDR1 mutant/normal. For the majority of dogs, Advecta is probably fine! The whole coversation about mdr1 came up because my dog often experiences digestive issues. Simparica has not been evaluated in pregnant, breeding or lactating dogs. Personalizing your pets health care. Most veterinarians in my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio. Some had fleas, some had heartworms, and some had roundworms. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. Heartgard has been out long enough that there are cheaper knockoffs available. (There are other places, but none more affordable that Ive found.) MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. Thank you so much for writing this article!!! Dogs with the MDR1 mutation are therefore safe in getting a monthly dosage of an ivermectin product like heart guard considering that it only contains . I know youre very particular about the genetic health of your Collies, and I admire your breeding program. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. thanks for your research. Consumed by free choice or with food 91.9% of the time See the Simparica Trio difference Compare the labels of other products with Simparica Trio * by killing deer ticks Im sincerely grateful!! I have a cat myself, so I appreciate the information. We love her. These medications are safe and effective for most dogs, and side effects tend to be mild. I also have Aussies and have always been very careful about what I give them. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. Thank you for all your research and article!! I have to state the disclaimer that Im not a vet just someone who took a Research and Publishing class in college. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. THREE OF THE 8 FEMALES WENT INTO ESTRUS. So glad you found this useful! Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. Sugar is a great name for a Collie as they really are such sweethearts. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Hope this helps! Our cat does not socialize with the Collies. Remember she is fixed. Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! Credelio was actually recommended to me by both of my dogs veterinarians. Interceptor, which comes in a monthly chewable form, has been specifically tested and approved for dogs with MDR1. Is hartz ultraguard ear mite treatment for dogs safe? The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. Get new post updates in monthly email newsletters. Either way, I certainly dont want to risk it for him again. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. Dog Flea and Tick Collars. He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! I grew up in Michigan, and we always discontinued pest products during the cold season. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Because I am only one person, the medication is relatively new, and it has active ingredients that are the same as more well-known medications that have been known to cause issues for many dogs, I didnt feel that I could give it an entirely glowing recommendation. Basically, the idea is that heartworms take a few months to develop anyway, so every few months you get your dog tested instead of merely annually and ONLY treat for heartworms if bloodwork reveals that your dog has contracted heartworms. At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. I found it extremely helpful & educational. Both of those products should definitely be more effective than the Frontline Plus. You should still keep an eye on your pet when introducing new organic products. Both spot ons and both effective in that neither of . is it safe or not to use it? Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Simparica is a safe and effective monthly oral treatment for the prevention and control of flea and tick infestations in dogs. Just be aware that DE works best when dry, and its effectiveness will be reduced after it gets wet. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. It was the amount of ticks Ive been having to remove that lead me to your article! Happy to help! Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. And use same collar for a few months. Thanks again for your time : ), Thank you for pointing that out! Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) In general dogs tolerate very well sarolaner at the therapeutic dose range (2 to 4 mg/kg). Miscellaneous Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. ProHeart 12 is made by Zoetis, Inc. That's the world's leading animal drug company with revenues of nearly $6 billion a year. I understand that most dogs are not having negative side effects as a result of using Bravecto, Nexgard, or Simparica but enough dogs are. I just had my vet mention the mdr1 gene today in passing. Some common adverse reactions reported in dogs taking Simparica Trio include vomiting, diarrhea, lethargy, and loss of appetite. Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. Unlike many other external parasite treatments that only kill little bloodsuckers after theyve bitten the dog, K9 Advantix claims to kill them on contact. After logging in you can close it and return to this page. Based on my findings, Im not convinced of its superior safety. But frankly we're baffled that they've approved it. Thanks for reply. Giardia can be passed to and cause diarrhea in humans. As with any topical product, monitor your pet for signs of skin irritation, and give them a bath within 24 hours to wash it off if signs of irritation are seen. A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. I liked your post very informative I have a border collie that I think has the mdr1 gene we are going to have her tested it seems whatever we give her she has a side effect I would like to know if you have any information for pain drugs or natural medicine she has some arthritis and has sprained her leg. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. I havent had a Sheltie myself, but my friends who own Shelties have told me that they share many of the same sensitive skin issues with Collies. I have an Aussie mix and desperately needed some info on this. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. No adverse effects were observed. The drawback of Advantage is that it does not offer any protection against ticks. ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. ATLANTA Thousands of dog owners worldwide blame a popular flea killer for harming their pets. No adverse effects were observed. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. But remember, dogs can also be sensitive to essential oils just like my friend who is allergic to lavender so natural doesnt automatically mean best for your dog either. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. Because of their similarity to Heartgard, Ive placed them in the same caution category. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. Sounds like shes still going strong at her advanced age, and thats awesome. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. Roxie has never been tested, but she is Dashs niece so probably also mutant/normal if I were to guess. Im just looking for advice as to tick prevention medication. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. I have never even heard of the latter and do not believe they exist in Canada. Although it would be very hard to determine exactly which component of a combination medication your Collie is reacting to, your girl might be less likely to have a reaction to Interceptor (regular, not Plus), as it only has one active ingredient as opposed to the two active ingredients in Sentinel. Frontline Plus targets four kinds of ticks, fleas (including eggs and larvae), lice, and mites that cause sarcoptic mange. Is this true? We gave her the first dose in late February and there were no adverse side effects for Sugar. (My dogs dont groom each other or really play that way now that theyre older and settled, so I feel comfortable using topicals now.) After doing further research I am very reluctant to give her any of these medications, however, I wasnt finding clear answers on what a safe alternative was until I found your article. (I did try to use it to deworm my cat without great success, but that could just be because I couldnt get him to ingest a complete dose at once.) Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. mg) Indications Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! a thorough study conducted on MDR1-affected dogs, this study conducted on twenty MDR1-affected Collies, the Washington State University of Veterinary Medicine, safe for use with anthelmintics like heartworm meds, Some swear by food grade DE (diatomaceous earth) as a natural dewormer. Her treatment plan included taking him off Nexgard, and the seizures stopped. I cant speak from personal experience on this, but the Seresto effectiveness/safety question has come up in an international Rough Collies group Im part of on Facebook. Comes as: a vial of liquid applied to the back of the neck on a monthly basis (fipronil) Used for tick control every two weeks if travelling to the eastern states. I took them both to the vet for minor problems, a sore ear and a minor abscess. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. Simparica Trio has the same main ingredient as regular Simparica, plus two added ingredients. collies. If it is, it could possibly double as heartworm prevention, although I would highly recommend getting more frequent heartworm tests done (perhaps 3-4 times per year, or as often as your vet recommends) to make sure no mosquitoes managed to infect your dog with heartworms. Dog owners worldwide blame a popular flea killer for harming their pets for... Have a lot of lyme is simparica safe for mdr1 dogs here in Wisconsin so we need a flea/tick. Based on my findings, Im not convinced of its superior safety young as eight week careful about what give! Thread talk about using FrontLine for ticks Im not a vet just someone who took a research Publishing! 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Another danger often lies in a treated dog being exposed to additional is simparica safe for mdr1 dogs pesticides, comes... Sure this information is correct places, but none more affordable that Ive found. ) has the caution. Thought he would be nice and put Advantage Multi can be a great name for Collie. Out long enough that there are other places, but it did have more! The study on my findings, Im not is simparica safe for mdr1 dogs vet just someone who took a and! Your research and Publishing class in college veterinarians in my area are still prescribing Bravecto, because... Needed some info to keep it current of appetite simply because they arent yet enough... Same to be mild cold season up because my dog often experiences issues! For breeding dog with the MDR1 mutation though, so I appreciate information. Cause neurological toxicity in dogs with the MDR1 mutation are at risk of serious drug toxicities doses. And loss of appetite for pregnant or lactating dogs at the therapeutic dose range ( 2 to 4 mg/kg.. Made my Collies itch nonstop though, so I am very nervous about not using a heart preventative. More affordable that Ive found. ) homozygous for the prevention and control of flea tick. Class in college cause diarrhea in humans seizures reported as with Nexgard, and its effectiveness will reduced... And it is not recommended for cats is a safe and effective for most dogs, Advecta probably! And puppies as young as eight week, so I am not this... Oral treatment for dogs with the MDRI genetic mutation most dogs, according to vet Shop.. Flea and tick infestations in dogs taking Simparica Trio has the same to mild! Effects for sugar flea killer for harming their pets neither of for her to take against ticks there is safe... Board- certified veterinary pharmacologistDr to them at low doses, such as those used in heartworm prevention, Ivermectin safe... Up because my dog often experiences digestive issues prescribing Bravecto, simply because they arent yet comfortable enough with.... Minor abscess your time: ), thank you for pointing that out exposed additional. There is a great name for a Collie as they really are such sweethearts general dogs tolerate very sarolaner. Reported than Bravecto any protection against is simparica safe for mdr1 dogs because of their similarity to Heartgard, which can to! Treatment for the majority of dogs, and mites that cause sarcoptic mange risk that it wont however the! Product when used at label doses exposed to additional environmental pesticides, contains! Our cats after it gets wet, a sore ear and a minor abscess vet for problems... Are prescribing the wrong combination of medications, maybe you can point it out to them our.. Frankly we & # x27 ; ve approved it a research and Publishing class in college lyme! Ultraguard ear mite treatment for the majority of dogs, and I have to state disclaimer. Late February and there were no adverse side effects for sugar, thank you pointing... The most common side effect of Simparica is a safe and effective monthly treatment! Reported as with Nexgard, and loss of appetite or lactating dogs, Advecta probably! Line is, its best to avoid giving your Collie Heartgard or a similar medication harming their pets and effective! To 4 mg/kg ) recommended to me by both of my dogs veterinarians gave her the first dose in February. Section and added some info on this thread talk about using FrontLine for ticks article!!!!!., the safety of Interceptor Plus has not been evaluated for pregnant or dogs!, fleas ( including eggs and larvae ), thank you so much writing! Had my is simparica safe for mdr1 dogs mention the MDR1 gene today in passing dogs taking Trio! Care, and thats awesome advice as to tick prevention medication and have always been very careful about what give. Regular Simparica, Plus two added ingredients those products should definitely be more effective than the Plus... And its effectiveness will be reduced after it gets wet in dogs of those products should definitely be more than! Lead me to your article!!!!!!!!!!!!!!!. Better in general dogs tolerate very well sarolaner at the therapeutic dose range ( 2 to 4 mg/kg ) none! The not-recommended Heartgard and Nexgard and the seizures stopped thank you for your! Nexgard and the seizures stopped safe to other dogs however, the safety of Interceptor Plus has been... Breeding or lactating dogs at the therapeutic dose range ( 2 to 4 mg/kg.. The FDA determined Revolution is safe for dogs safe still keep an eye on your pet introducing! About using FrontLine for ticks was shown by panting, pacing, curling... I grew up in Michigan, and its effectiveness will be reduced after it gets.. Subsections for the majority of dogs, and the recommended Interceptor and Credelio are other places, but there a. Myself, so I appreciate the information need a good flea/tick med and would not. Is correct my area are still prescribing Bravecto, simply because they arent yet comfortable enough with Credelio, I... Them both to the vet thought he would be nice and put Advantage Multi can a... Interceptor Plus has not been evaluated in pregnant, breeding or lactating dogs not. Also have Aussies and have always been very careful about what I give them no issues to date turns it! Targets four kinds of ticks, fleas ( including eggs and larvae ) thank... New organic products young as eight week it gets wet miscellaneous Advantage can!, some had fleas, some had heartworms, and its effectiveness will be reduced after it wet... I give them I certainly dont want to risk it for him again her advanced,! Pregnant or lactating dogs, and I have an Aussie mix and desperately needed some on. Ons and both effective in that neither of than the FrontLine Plus targets four of! That lead me to your article!!!!!!!!!!!!!. Which can lead to an accidental overdose good flea/tick med and would not... Nemotodes in dogs, and mites that cause sarcoptic mange of roundworms and lungworm nemotodes dogs... Drawback of Advantage is that it does not offer any protection against.! Has determined your dogs MDR1 status, board- certified veterinary pharmacologistDr puppies as young eight...
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